EPIsoDE Study - phase 2b clinical trial
The EPIsoDE study, in which the MIND Foundation participated as a junior partner, has recently been completed. This phase-2b clinical study, led by the Central Institute for Mental Health (ZI) Mannheim and Charité – Universitätsmedizin Berlin, investigated the efficacy and safety of psilocybin in treatment-resistant unipolar depression. During the study, 144 patients received either a high/therapeutic dose, a low dose, or a control substance to evaluate the antidepressant effects of psilocybin. EPIsoDE is the largest publicly funded and clinical trial with psilocybin to date.
The main goal of the EPIsoDE study was to determine whether psilocybin has a better antidepressant effect than a placebo and to identify the most effective dosage. Initial results from other studies suggest that psilocybin, when used in a psychotherapeutic context, could be promising, particularly for patients for whom other treatments have failed.
The MIND Foundation is proud to have been part of this significant step in psychedelic research and remains committed to contributing to the exploration and application of innovative therapies.